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Xanax affects the central nervous system, meaning it interacts with various substances in ways that can increase sedation, impair coordination, or slow breathing. One of the most dangerous combinations is Xanax with alcohol. Both depress the central nervous system, and taking them together significantly increases the risk of extreme drowsiness, respiratory depression, coma, or death. Opioids pose a similar risk, and the FDA has issued warnings about the potentially fatal consequences of combining benzodiazepines with opioid medications. Other sedatives, sleep aids, muscle relaxants, and certain antihistamines may also interact with Xanax. Even some herbal supplements, such as kava or valerian root, can increase sedation when taken together. Patients should always inform their healthcare provider about all medications and supplements they use to avoid interactions. Individuals with respiratory conditions—such as sleep apnea or chronic obstructive pulmonary disease—should use Xanax cautiously, as it may worsen breathing difficulties. Older adults may experience heightened side effects, including confusion, falls, and impaired coordination. Driving or operating heavy machinery should be avoided until the patient fully understands how Xanax affects alertness. Safe storage is also essential; Xanax should be kept securely and out of reach of children or anyone for whom the medication is not prescribed. Sharing prescription medications is illegal and unsafe. These safety precautions help ensure that Xanax is used responsibly and effectively under medical supervision.